Monogenic Obesity
Initial knowledge on the genetic involvement in monogenic obesity was derived from large-scale linkage analysis in obese mice carrying naturally occurring mutations. These analyses have pointed to disease-related loci and have identified the majority of gene mutations leading to monogenic obesity in mice 3 . In particular, the genetic characterization of naturally occurring obese animal models, such as ob ob, db db, fat and tubby mice, led to the discovery of recessive mutations in the genes...
Contributors
Caroline Apovian, MD Division of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA Eirini Bathrellou, MSc Department of Nutrition and Dietetics, Harokopio University, Athens, Greece George L. Blackburn, PhD, MD Division of Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Susann Bluher, MD Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany and Division of...